Inhibition of rat liver glucokinase by alloxan and ninhydrin.
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چکیده
منابع مشابه
Inhibition by catecholamines of the induction of rat liver glucokinase.
Epinephrine, norepinephrine, and isoproterenol prevent the induction of rat liver glucokinase (EC 2.7.1.2) produced by the administration of glucose to animals with low levels of the enzyme. The low levels of glucokinase were obtained by feeding the animals a carbohydrate-free diet for 6 days. When epinepbrine was given 4 hours after the administration of carbohydrate there was only a slight in...
متن کاملHepatic glucokinase in the fed, fasted, and alloxan-diabetic rat.
Although impairment of glucose utilization by the liver is a characteristic feature of the alloxan-diabetic rat (l-3), the metabolic site of this block is not certain. Tracer studies with C14labeled glucose, carried out in liver slices, suggest that glucose phosphorylation is the affected step (1, 3); however, there is a dearth of information concerning the enzyme system responsible for glucose...
متن کاملAlternative splicing of glucokinase mRNA in rat liver.
The sequences of two near full-length cDNAs encoding rat liver glucokinase are reported. One of the cDNAs is essentially identical to the cDNA cloned by Andreone, Printz, Pilkis, Magnuson & Granner. [(1989) J. Biol. Chem. 264, 363-369]. The other cDNA contains a 151 bp insertion and a downstream 52 bp deletion. The inserted block of bases has been shown to originate from an optional cassette ex...
متن کاملInsulin-dependent Synthesis of Liver Glucokinase in the Rat.
A glucokinase qualitatively and quantitatively adequate as the first and limiting step in the synthesis of glycogen from glucose has been recently identified in the liver of the normal fed rat. In contrast with hexokinase, glucokinase activity was found to disappear in fasted and alloxan-diabetic animals (1). A characteristic shared by deprivation of food and diabetes is the marked decrease of ...
متن کاملMechanism of alloxan-induced calcium release from rat liver mitochondria.
The objective of the present work was to investigate the mechanism of alloxan-induced Ca2+ release from rat liver mitochondria. Transport of Ca2+, oxidation and hydrolysis of mitochondrial pyridine nucleotides, changes in the mitochondrial membrane potential, and oxygen consumption by mitochondria were investigated. Alloxan does not inhibit the uptake of Ca2+ but stimulates the release of Ca2+ ...
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ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 1986
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.34.4731